Among numerous types of dog species, great danes present a significant feature. This distinct feature can be seen, as Danes have many different kinds of color patterns on their body. Generally speaking, three gene series are responsible for assigning the patterns to which great danes will exhibit. These series are called M-series, H-series and S-series and they this article will examine these genes.

In order to understand these genetic traits, we must first understand genes and alleles. For those unfamiliar with the term allele, an allele is any one of a number of feasible DNA codings of the same gene. In the case of the great dane, M-series genes, have two alleles: namely, merle and not-merle. If two dominant merles run into one another in a locus, the dog's color changes its state to purely white [except for some regions in head and tail]. Nevertheless, when one of the genes are recessive, the coat color is turned into shaded blue with irregular patches of black.

A Herlequin gene, [otherwise known as H-series] is an incomplete dominant and carry two alleles. If a dog has recessive genes in her locus, the dominant gene will have no effect on the great danes appearance. There may be some irregular black patches, but shaded blue areas become fully white.

S-series accounts for white spots on a great danes body. When two dominant S-series genes come together in a locus, white in the body is likely to diminish, about 5% or less, and there remains a little white at chest and feet. The fact that one of the genes is recessive results in the increase in the amount of white on the chest, face, feet and neck. The dog will have approximately 25% of its hair appear white in color.

There are three more possibilities that occur when the alleles come together abnormally. For instance, SSI (Sporophytic Self-Incompatibility Systems) alleles commonly label a great dane as having pet-marked-blacks. This odd name is derived from the appearance of the coats white color -- which appears as a black hue. Dogs carrying SSW alleles tend to resemble Irish marked dogs. Perhaps this is because their gene type is exactly the same as those of the Irish marked dog. Ironically, SISW alleles lead to a completely dominant white color in dog's body. The result is typically that of a white great dane having the appearance of a Boston head.